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30 The development of novel, last-resort interventional treatment therapies is crucial to also relief pain in these refractory patients. 89 Despite the development and use of many pharmacological drugs and guidelines for the treatment of chronic neuropathic pain over the years, 8 a substantial amount of neuropathic pain patients remain undertreated or untreated, with less than 50% of patients responding to pharmacological treatment. 13 The international association for the study of pain defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system” and classifies chronic neuropathic pain as a disease under International Classification of Diseases 11th Revision ( ICD-11).
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Neuropathic pain is a complex, heterogeneous disorder that affects approximately 8% of the total adult human population and comes with significant burden for both the patient and health care system. IASP Presidential Task Force on Cannabis and Cannabinoid Analgesia.PAIN 2014: Global Year Against Orofacial Pain.PAIN 2015: Global Year Against Neuropathic Pain.PAIN 2016: Global Year Against Pain in the Joints.PAIN 2017: Global Year Against Pain After Surgery.PAIN 2018: Global Year for Excellence in Pain Education.PAIN 2019: Global Year Against Pain in the Most Vulnerable.PAIN 2020: Global Year for the Prevention of Pain.PAIN 2022: Global Year for Translating Pain Knowledge to Practice.